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- Steady-state chemoreflex drive captures ventilatory acclimatization during incremental ascent to high altitude: effect of acetazolamide
- Valerie C. Cates (author); Christina D. Bruce (author); Anthony L. Marullo (author); Rodion Isakovich (author); Gurkarn Saran (author); Jack K. Leacy (author); Ken D. O'Halloran (author); Thomas D. Brutsaert (author); Mingma T. Sherpa (author); Trevor A. Day (author); Library OA fund (funder); Alberta Government Student Temporary Employment Program (funder); Alberta Innovates Health Solutions Summer Studentships (funder); Natural Sciences and Engineering Research Council (NSERC) Undergraduate Student Research Assistantships (funder); NSERC Discovery Grant Program (funder); University College Cork (funder)
- Date issued
- 2022-12; 2022-12
- Ventilatory acclimatization (VA) is important to maintain adequate oxygenation with ascent to high altitude (HA). Transient hypoxic ventilatory response tests lack feasibility and fail to capture the integrated steady-state responses to chronic hypoxic exposure in HA fieldwork. We recently characterized a novel index of steady-state respiratory chemoreflex drive (SSCD), accounting for integrated contributions from central and peripheral respiratory chemoreceptors during steady-state breathing at prevailing chemostimuli. Acetazolamide is often utilized during ascent for prevention or treatment of altitude-related illnesses, eliciting metabolic acidosis and stimulating respiratory...
- Appears in collection(s)
- Science and Technology